Once an OpenEdge Replication agent is removed from the properties file, it should not be added again unless the target database is recreated from the source database. This is because the source and target databases may not be synchronized, which will cause a failure.

Do not rename an OpenEdge Replication agent after OpenEdge Replication has been started once.

You can add an OpenEdge Replication agent (the maximum is two agents in total) as long as the target databases are created as instructed.