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About the Oracle Wire Protocol Driver : Support for Multiple Environments : Support for macOS Environments : 64-bit Driver Requirements for macOS
  

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64-bit Driver Requirements for macOS
*All required network software that is supplied by your database system vendors must be 64-bit compliant.
*If your application was built with 32-bit system libraries, you must use 32-bit driver. If your application was built with 64-bit system libraries, you must use the 64-bit driver (see "32-bit Driver Requirements for macOS"). The database to which you are connecting can be either 32-bit or 64-bit enabled.
*iODBC Driver Manager, version 3.52.7 or higher, is required.
*The following processors are supported:
*Intel
*The following operating systems are supported for your 64-bit driver. All editions are supported unless otherwise noted.
*macOS v10.12.x (Sierra)
*Mac OS X v10.11.x (El Capitan)
*Mac OS X v10.10.x (Yosemite)
*Mac OS X v10.9.x (Mavericks)